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A macro creatine kinase isoenzyme in serum of apparently healthy individuals

Whelan, P.V.; Malkus, H.

Clinical Chemistry 29(7): 1411-1414

1983

ISSN/ISBN: 0009-9147
PMID: 6345029
Document Number: 200754
Activity of creatine kinase B subunit, as measured by an immunoinhibition assay, is persistently increased in certain healthy, asymptomatic adults, whose values for total CK activity are within normal limits. Serum samples from two such individuals were investigated by electrophoresis, heat inactivation, determination of activation energies, and immunosorption (on protein A). The results demonstrated the presence of a circulating complex of IgG and CK-BB, which has been described as macro CK, type I. To our knowledge, this is the first report of such macro CK isoenzymes in healthy individuals.

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Wu, A.H.; Bowers, G.N. 1982: Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals Clinical Chemistry 28(10): 2017-2021
Green, T.R.; Golper, T.A.; Swenson, R.D.; Pulliam, J.P.; Morris, C.D. 1986: Diagnostic value of creatine kinase and creatine kinase MB isoenzyme in chronic hemodialysis patients: a longitudinal study Clinical Nephrology 25(1): 22-27
Chapelle, J.P.; Heusghem, C. 1980: Further heterogeneity demonstrated for serum creatine kinase isoenzyme MM Clinical Chemistry 26(3): 457-462
Miles, M.P.; Schneider, C.M. 1993: Creatine kinase isoenzyme MB may be elevated in healthy young women after submaximal eccentric exercise Journal of Laboratory and Clinical Medicine 122(2): 197-201
Medeiros, L.J.; Walsh, D.; Gerson, B. 1986: Interference by macro creatine kinase type 1 with an immunoenzymometric method for quantification of CK-MB in serum Clinical Chemistry 32(4): 710-711
Flenker, I.; Bauer, G.; Sabin, G.; Ricken, D. 1980: Serum creatine kinase isoenzyme activities in pulmonary diseases Die Medizinische Welt 31(31-32): 1130-1132
Van Steirteghem, A.C.; Zweig, M.H.; Schechter, A.N. 1978: Radioimmunoassay of creatine kinase isoenzymes in human serum: isoenzyme MM Clinical Chemistry 24(3): 414-419
Keshgegian, A.A.; Feinberg, N.V. 1984: Serum creatine kinase MB isoenzyme in chronic muscle disease Clinical Chemistry 30(4): 575-578
Jurlander, B.; Clemmensen, P.M.; Ohman, E.M.; Wagner, G.S.; Grande, P. 1992: Serum creatine kinase isoenzyme MB and myoglobin in patients with acute myocardial infarction and coronary reperfusion Ugeskrift for Laeger 154(39): 2682-2686
Mall, T.; Scholer, A.; Burckhardt, D. 1982: Creatine kinase (CK) activity and its isoenzyme MB in the serum of randomly selected patients without acute coronary disease Schweizerische Medizinische Wochenschrift 112(29): 1039-1045
Hamlin, C.; Ackerman, E. 1978: Relative merits of two electrophoretic and two column-chromatographic kets for determining serum creatine kinase isoenzyme MB activity Clinical Chemistry 24(11): 2013-2017
Heinbokel, N.; Hoo, J.J.; Goedde, H.W.; Latta, E.; Buckwald, S. 1983: Activity of the creatine kinase isoenzyme CK-BB in the serum of neonates as an indicator of perinatal damage to the central nervous system Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft für Kinderheilkunde 131(5): 282-285
Kashani, M.; Leonetti, H.B.; Ardizzone, J. 1984: Immunochemical assay of creatine kinase isoenzyme MB and lactate dehydrogenase isoenzyme 1 Clinical Chemistry 30(8): 1417
Chape, E.; Hyde, T. 1984: Lactate dehydrogenase isoenzyme 6 with increased creatine kinase BB isoenzyme Clinical Chemistry 30(1): 153-154
El Allaf, M.; Chapelle, J.P.; el Allaf, D.; Adam, A.; Faymonville, M.E.; Laurent, P.; Heusghem, C. 1986: Differentiating muscle damage from myocardial injury by means of the serum creatine kinase (CK) isoenzyme MB mass measurement/total CK activity ratio Clinical Chemistry 32(2): 291-295
Fukuda, J.; Yagishita, S.; Yamaoka, K.; Hanihara, T.; Kushida, K.; Murayama, H. 1994: Creatine kinase isoenzyme BB increased in serum and tumor tissue of patients with giant cell tumor of bone Clinical Chemistry 40(11 Part 1): 2064-2065
Szász, G.; Kinne, E.; Colombo, J.P.; Gruber, W. 1979: Influence of indicating enzyme reaction on apparent creatine kinase activity creatine kinase in serum, VII Journal of Clinical Chemistry and Clinical Biochemistry 17(11): 689-691
Gerhardt, W.; Waldenström, J.; Hörder, M.; Hofvendahl, S.; Billström, R.; Ljungdahl, R.; Berning, H.; Bagger, P. 1982: Creatine kinase and creatine kinase B-subunit activity in serum in cases of suspected myocardial infarction Clinical Chemistry 28(2): 277-283
Yasmineh, W.G.; Ibrahim, G.A.; Abbasnezhad, M.; Awad, E.A. 1978: Isoenzyme distribution of creatine kinase and lactate dehydrogenase in serum and skeletal muscle in Duchenne muscular dystrophy, collagen disease, and other muscular disorders Clinical Chemistry 24(11): 1985-1989
Roe, J.; Brien, T.G. 1976: More on creatine kinase isoenzyme MB determination Clinical Chemistry 22(10): 1753