Ectopic calcifications in adult hypophosphatasia
Frustaci, A.; Gentiloni, N.; Coiana, G.; Breccia, F.
Minerva Medica 74(27): 1651-1654
1983
ISSN/ISBN: 0026-4806 PMID: 6856174 Document Number: 200291
The first case of hypophosphatasia in adults reported in Italy (20th in the world) is described with remarks on the epidemiology, pathogenesis and therapeutic possibilities. The formation of renal and cholecystic calculi after long-term, intensive vitamin D and Calcium therapy indicates the limited capacity of pyrophosphate (PPi), even in large doses, to prevent the precipitation in man of calcium and phosphorus and the subsequent formation of ectopic calcifications.