Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial
Kamondetdecha, R.; Tannirandorn, Y.
Journal of the Medical Association of Thailand 91(3): 282-286
2008
ISSN/ISBN: 0125-2208 PMID: 18575278 DOI: 10.1016/j.acpain.2008.05.022Document Number: 199942
Objectives: To evaluate efficacy of ibuprofen compared with acetaminophen for relief of perineal pain after childbirth, side effects of ibyprofen compared with acetaminophen and patient satisfaction in treatment between the 2 groupsMaterial and Method: A total of 210 women who gave birth by spontaneous vaginal delivery with mediolateral episiotomy between June 2006 and November 2006 were randomly assigned to receive either ibuprofen (400 mg) (n = 106) or acetaminophen (1000 mg) (n = 104), both given orally when suturing was completed. Pain 1 9 ratings were recorded before the treatment and at 1, 2, 3 and 4 hours after the treatment on a 10-cm visual analogue scale. Side effects and patient satisfaction were assessed at 24 hours.Results: Pain in the ibuprofen group was considerably more reduced than the acetaminophen group at I hour of treatment (mean pain rating 2.18 vs. 2.88, respectively; p < 0.003). Even though, at 2, 3 and 4 hours of treatment ibuprofen seemed to give more relief of pain than acetaminophen, they did not reach statistically significant differences (mean pain rating; at 2 hour: 1.59 vs. 1.97, p = 0.093; at 3 hour: 1.08 vs. 1.31, p = 0.183; and at 4 hour: 0.69 vs. 0.85, p = 0.169; respectively). There were no side effects and no significant differences in overall patient satisfaction between the two groups.Conclusion: Ibuprofen was consistently better than acetaminophen at 1 hour after treatment for relief of perineal pain after childbirth without any side effects. After 2 hours, ibuprofen and acetaminiphen had similar analgesic properties.
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