Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients
Yang, H.; Qiu, L.; Chen, G.; Ye, Z.; Lü, C.; Lin, Q.
Fertility and Sterility 89(3): 656-661
2008
ISSN/ISBN: 1556-5653 PMID: 17543960 DOI: 10.1016/j.fertnstert.2007.03.037Document Number: 199616
To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women. Prospective, case-control study. Large public hospital in a major city in China. Twenty-five URSA patients and 34 normal, early pregnant, control women. Measurements of CD4(+)CD25(+) regulatory T cells in decidua and peripheral blood. The proportion of CD4(+)CD25(bright) regulatory T cells; the percentage of CD25(bright) cells in the CD4(+) T-cell population. The proportions of CD4(+)CD25(bright) T cells in both decidua and peripheral blood in URSA patients were statistically significantly lower than those in control women. Meanwhile, the percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly lower in URSA patients than in control women. The percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly higher than that in peripheral blood in control women, whereas the difference was not significant in patients who have URSA. Human CD4(+)CD25(bright) T cells play a major role in tolerating conceptus antigens and therefore may contribute to the maintenance of pregnancy. The data suggest that CD4(+)CD25(+) regulatory T cells may be a novel target in URSA therapy.
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