Inhibition of cyclic nucleotide phosphodiesterase from rabbit heart by hydroxypyridines
Polyansky, N.B.; Smirnov, L.D.; Shvedova, A.A.; Kagan, V.E.; Tkachuk, V.A.
Voprosy Meditsinskoi Khimii 29(1): 123-127
1983
ISSN/ISBN: 0042-8809 PMID: 6301154 Document Number: 199557
3-Hydroxypyridines, which are inhibitors of cyclic nucleotide phosphodiesterase, affected reversibly and non-competitively the enzyme molecule as compared with cAMP. A number of substances was found exhibiting high inhibitory and antioxidant activities, high inhibitory and low antioxidant activities, as well as low inhibitory and high antioxidant activities. Elucidation of the 3-hydroxypyridines action via antioxidant or phosphodiesterase pathways became possible.