Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency
Mitas, J.A.; Mosley, C.A.; Drager, A.M.
Southern Medical Journal 76(4): 462
1983
ISSN/ISBN: 0038-4348 PMID: 6836360 Document Number: 199456
Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities. Six patients had relief of pain within five days of initiation of therapy. One patient had no pain relief despite mood alteration. The relief of pain persisted whether renal function was stable or declining. This form of therapy is safe and as effective in patients with neuropathic pain and mild to moderate renal insufficiency as in patients with normal renal function.