Effects of CCR2 and CCRS polymorphisms on HIV-1 infection in Thai females
Wichukchinda, N.; Nakayama, E.E.; Rojanawiwat, A.; Pathipvanich, P.; Auwanit, W.; Vongsheree, S.; Ariyoshi, K.; Sawanpanyalert, P.; Shioda, T.
Journal of Acquired Immune Deficiency Syndromes 47(3): 293-297
2008
ISSN/ISBN: 1525-4135 PMID: 18197127 DOI: 10.1097/qai.0b013e318162caabDocument Number: 199327
Polymorphisms in CCR2 and CCR5 genes reportedly affect HIV-1 transmission and disease progression in HIV-1-infected individuals. In the study presented here, we examined the effects of CCR2 and CCR5 polymorphisms on HIV-1 transmission in 74 Thai females who were exposed to HIV but seronegative (ESN) and in 347 HIV-seropositive females. We found that the combination of 2 non-synonymous substitutions, CCR2 V641 and CCR5 G316A, tended to occur more frequently in ESN females (2 of 74) than in HIV-1-infected females (I of 347) (P = 0.08). This suggested that non-synonymous substitution in the CCR5 gene also affects HIV-1 transmission in an Asian population in which the CCR5-Delta 32 is very rare.