Low-resolution autoradiography in rat brain after administering labelled CDP-choline
Romero, A.; Serratosa, J.; Sacristán, A.; Ortiz, J.A.
Arzneimittel-Forschung 33(7a): 1054-1056
1983
ISSN/ISBN: 0004-4172 PMID: 6684465 Document Number: 198948
14C-Methyl labelled cytidine diphosphate choline (CDP-choline, citicoline, Somazina) at a dose of 10 microCi has been administered orally to rats. Half of animals were sacrificed at 5 h, and other half at 24 h after administration. Autoradiography preparations of brain were isolated according to a relevant method for optical microscopy examination. Extra- and intracellular distribution of the drug after different unlabelling times has been studied. The intracellular radioactivity was checked 24 h after administration.