The effects of intravenous anesthetics, propofol, fentanyl and ketamine on the excitability of spinal motoneuron in human: an F-wave study
Kakinohana, M.; Motonaga, E.; Taira, Y.; Okuda, Y.
Masui. Japanese Journal of Anesthesiology 49(6): 596-601
2000
ISSN/ISBN: 0021-4892 PMID: 10885234 Document Number: 1987
We have investigated the effects of various intravenous anesthetics, propofol, fentanyl and ketamine on the excitability of spinal motoneuron using an F-wave analysis in a total of 28 patients. All patients were divided randomly into three groups as follows; 2 mg cntdot kg-1 intravenous bolus injection followed by 6 mg cntdot kg-1 cntdot h-1 infusion of propofol (P group), 1 mg cntdot kg-1 intravenous bolus injection followed by 1 mg cntdot kg-1 cntdot h-1 infusion of ketamine (K group), and 5 mug cntdot kg-1 injection of fentanyl (F group). The F-wave was determined after supramaximal electrostimulation of the median nerve in distal point. After establishing stable baseline values, intravenous injection of one of the three anesthetics was applied. The F-wave was recorded 3 minutes after the time of bolus administration. We found a significant (P = 0.018) reduction of the persistence from 77.5 +- 15.2 to 40.9 +- 16.8% in the propofol group. On the other hand, no significant changes in F-wave parameters were found in ketamine, or fentanyl group. These results suggested that motoneuron excitability in spinal cord could be inhibited by anesthetic dose of propofol, but not by ketamine or fentanyl.
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