Zollinger-Ellison syndrome with esophagitis and Barrett mucosa
Karl, T.R.; Pindyck, F.; Sicular, A.
American Journal of Gastroenterology 78(10): 611-614
1983
ISSN/ISBN: 0002-9270 PMID: 6624733 Document Number: 197201
Although esophageal disease in Zollinger-Ellison syndrome is being recognized with increasing frequency, Barrett esophagus is seen only rarely. Basal lower esophageal sphincter pressure is probably not different in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome patients. Circulating gastrin, therefore, cannot be the major determinant of lower esophageal sphincter pressure in vivo. Total gastrectomy and resection of all metaplastic esophagus, when feasible, is the treatment of choice for patients with Zollinger-Ellison syndrome and Barrett mucosa.