Studies into human foetal pancreas--critical appraisal of methods for tissue preparation
Reiher, H.; Fuhrmann, K.; Woltanski, K.P.; Hahn, H.J.
Zentralblatt für Gynakologie 104(4): 213-220
1982
ISSN/ISBN: 0044-4197 PMID: 7043955 Document Number: 196455
3 different methods of legal abortion were administered to 23 patients who had requested termination of pregnancy between weeks 11-14 of pregnancy. In vitro studies into human fetal pancreas were taken into consideration when the choice was made. Carbohydrate tolerance was normal in all cases (50 g oGTT). Timing of intrauterine fetal death, in the context of the 3 above methods (B-scan ultrasonic diagnosis and HPL level measurement), as well as studies into in vitro stimulation of fetopancreatic insulin secretion, have shown purely mechanical, surgical abortion, sometimes following prostaglandin (PG) cervical gel priming, to be indispensable as a condition for successful in vitro elucidation of the etiopathogenesis of fetal diabetes. Extraamniotic PG induction of abortion has failed to yield any relevant information in that context. (author's)