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Prosthetic replacement for the thoracic vena cava: an experimental study

Fiore, A.C.; Brown, J.W.; Cromartie, R.S.; Ofstein, L.C.; Peigh, P.S.; Sears, N.S.; Deschner, W.P.; King, H.

Journal of Thoracic and Cardiovascular Surgery 84(4): 560-568

1982

ISSN/ISBN: 0022-5223
PMID: 6214671
Document Number: 195635
The superior vena cava (SVC) and thoracic inferior vena cava (IVC) were replaced in 46 dogs with autologus vein, knitted Dacron, glutaraldehyde-fixed porcine pericardium, unsupported polytetrafluoroethylene (PTFE) and externally stented PTFE. After 30 days, patency rates were determined by contrast venography and were 100, 0, 50, 75 and 100%, respectively. The patency rates of Dacron and glutaraldehyde-fixed pericardium are considered unacceptable when compared to autologous vein (P < 0.05). Stented PTFE exhibited a patency rate equal to that of autologous vein at 30 days, minimal graft reaction, excellent incorporation by host fibroblasts and a smooth neointima. The external spiral support added to PTFE enhanced the thromboresistance of this graft in the thoracic venous sytem. Long-term follow-up is required to determine if the stented PTFE prosthesis remains comparable to autologus vein as a venous conduit.

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