Spontaneous coronary artery dissection and eosinophilic inflammation: a cause and effect relationship?
Robinowitz, M.; Virmani, R.; McAllister HA JrU
American Journal of Medicine 72(6): 923-928
1982
ISSN/ISBN: 0002-9343 PMID: 7091163 Document Number: 195554
Spontaneous coronary artery dissection is described in 8 patients 26-47 yr of age. Six died suddenly, and 2 died after the onset of chest pain. All had normal heart weights and all had dissection of the left anterior descending coronary artery which occurred mainly in the outer 1/3 of the media. The adventitia of the dissected artery contained inflammatory infiltrates which were predominantly eosinophilic granulocytes. Forty-six cases previously published in 32 reports are reviewed. It is suggested that adventitial eosinophilic infiltrate may be responsible for spontaneous coronary artery dissection.