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Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients

Flanagan, R.J.; Storey, G.C.; Holt, D.W.; Farmer, P.B.

Journal of Pharmacy and Pharmacology 34(10): 638-643

1982

ISSN/ISBN: 0022-3573
PMID: 6128385
Document Number: 195535
Desethylamiodarone is the principal lipophilic metabolite of amiodarone present in plasma specimens from amiodarone-treatred patients. This structure was confirmed by probe-injection mass spectrometry of column effluent fractions and comparison with the authentic compound by both chromatographic and mass spectrometric techniques. Although there is no information available as to the pharmacological activity of desethylamiodarone in man, the plasma concentrations of this metabolite attained during chronic amiodarone therapy are similar to those of the parent compound (0.1-4 mg/l).

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