Determination of copper in liver puncture samples in the diagnosis of Wilson's disease
Wawschinek, O.; Beyer, W.
Journal of Clinical Chemistry and Clinical Biochemistry 20(12): 929-930
1982
ISSN/ISBN: 0340-076X PMID: 7182431 Document Number: 195156
Wilson's disease, a hereditary disorder of copper metabolism, is characterized by excessive storage of this metal in several organs. Storage of copper in liver tissue is of great importance in diagnosis and therapy. By means of the combination of two methods - low-temperature ashing and flameless atomic absorption - the copper determination can be made even in smallest liver samples (needle-biopsy samples). It is therefore possible to perform a histological examination, as well as a quantitative copper determination on one puncture sample.