Diagnostic-therapeutic trial in infantile genetic agranulocytosis with leucorecruitin
Burdach, S.E.; Evers, K.G.; Wissler, J.H.
Monatsschrift Kinderheilkunde Organ der Deutschen Gesellschaft für Kinderheilkunde 130(10): 789-791
1982
ISSN/ISBN: 0026-9298 PMID: 7177122 Document Number: 194969
Subject of this report is the usefulness of a biologically specific mediator of the leucocytosis reaction (leucorecruitin) in the diagnostic evaluation of granulopenic diseases. According to our trial the application of leucorecruitin in healthy humans resulted in a significant increase of granulocytes in circulating blood. The therapeutic effect depends on the neutrophil storage pool. In a diagnostic-therapeutic trial in infantile genetic agranulocytosis with depleted storage pools, leucorecruitin failed to lift the low number of circulating granulocytes to a normal level. No side effects could be observed so far.