The human HLA-DR antigens are encoded by multiple beta-chain loci
Hurley, C.K.; Nunez, G.; Winchester, R.; Finn, O.J.; Levy, R.; Capra, J.D.
Journal of Immunology 129(5): 2103-2108
1982
ISSN/ISBN: 0022-1767 PMID: 6811658 Document Number: 194878
Monoclonal antibodies have been used to isolate and characterize human HLA-DR antigens from human B cell lines. Using sequential immunodepletion experiments, several subsets of DR antigens have been identified. Partial amino-terminal amino acid sequencing has identified these subsets as DR molecules with sequences homologous to the murine I-E alloantigens. In addition, sequence data provide evidence for primary structural differences in the DR beta-chains of two of the subsets. These results provide primary structural evidence for the presence of multiple DR beta-chain loci.