The effects of trimebutine and metoclopramide on the gastroduodenal motility--by comparison with secretin-induced migrating motor complex
Nishioka, T.; Sekiguchi, T.; Kogure, M.; Kusano, M.; Kobayashi, S.
Nihon Heikatsukin Gakkai Zasshi 18(2): 105-113
1982
ISSN/ISBN: 0374-3527 PMID: 7154463 Document Number: 194786
The effects of trimebutine and metoclopramide on gastrointestinal motility were investigated in 8 healthy subjects and 12 patients with progressive systemic sclerosis and the effects were compared to those of secretin. Continuous manometric recordings from the stomach, duodenum and upper part of the jejunum were performed by the infused open-tip method. When secretin (2.0 U/kg) was administered i.v., gastrointestinal contractions resembling the spontaneous migrating motor complexes (MMC) were initiated in 15 of the 20 subjects (secretin-induced MMC: SI-MMC). Trimebutine (1.0 mg/kg) injected i.v. also produced a gastrointestinal motility similar to the SI-MMC in 9 of 10 subjects (trimebutine-induced MMC: TMB-MMC). The i.v. injection of metoclopramide (0.2 mg/kg) initially produced an acceleration of the gastrointestinal contractile activities, and .apprx. 40 min after the administration of metoclopramide contractile movements like the spontaneous MMC were observed in 4 of 5 subjects (metoclopramide-induced MMC: MCP-MMC). By comparison with the spontaneous MMC, in the SI-MMC the duration was shorter and the amplitude was smaller significantly. Moreover, the conduction velocity of the SI-MMC was significantly higher than that of the spontaneous MMC. Only the velocity of the TMB-MMC was significantly higher in comparison with the spontaneous MMC. The MCP-MMC did not differ significantly from the spontaneous MMC in their contraction rate, conduction velocity, amplitude and duration. Metoclopramide probably accelerates the initiation of the spontaneous MMC, but does not act directly on the MMC producing mechanisms. Both the i.v. injection and intraduodenal infusion of trimebutine produced similar effects; therefore it is assumed that trimebutine may act directly on the duodenal mucosa.