Case study of a diabetic dog with chronic membranous glomerulopathy treated with continuous intraperitoneal insulin infusion
Janle-Swain, E.; Thornhill, J.A.; Carter, J.M.; Hinsman, E.; Jackson, H.D.; Ash, S.R.
American Journal of Veterinary Research 43(11): 2044-2049
1982
ISSN/ISBN: 0002-9645 PMID: 6758639 Document Number: 194722
A chronic diabetic dog with membranous glomerulopathy and severe proteinuria was treated by continuous insulin infusion for 12 months. Hyperglycaemia was eliminated, but adjustments of the insulin infusion pattern were necessary. An initial kidney biopsy revealed fusion of the basement membrane foot processes, thickening of the basement membrane, and subendothelial deposition. After 5 months of infusion, there was less fusion of the foot processes and a decrease in the subendothelial deposition. Urinary protein loss decreased from 17.3 g/day to 625 mg/day after 2 months of infusion. The dog gained weight, muscle wasting was reversed, and stamina returned while on continuous insulin infusion.