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Effect of ascorbate deficiency on liver glycogen metabolism in guinea pig

Bandyopadhyay, S.; Banerjee, S.

Indian Journal of Experimental Biology 20(1): 44-47

1982

ISSN/ISBN: 0019-5189
PMID: 6749670
Document Number: 194502
Glycogen synthetase, phosphorylase and .alpha.-glucosidase activities in the liver tissue were determined in normal, scorbutic, insulin-treated scorbutic guinea pigs and in guinea pigs after recovery from scurvy. Liver glycogen were also determined in these animals. Development of scurvy had no effect on glycogen synthetase activity in the liver, whereas it caused increased phosphorylase and .alpha.-glucosidase activity. Insulin treatment of the scorbutic animals reversed the liver phosphorylase activity to normal, and .alpha.-glucosidase activity significantly diminished. When the scorbutic guinea pigs recovered from scurvy, both liver phosphorylase and .alpha.-glucosidase activities significantly diminished. Liver glycogen markedly decreased in the scorbutic guinea pigs. The value returned to normal after treatment with ascorbic acid and significantly increased after insulin treatment. The observed changes were possibly due to increased secretion of adrenaline (epinephrine) and diminished secretion of insulin in ascorbic acid-deficient guinea pigs.

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