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Dependence of radioprotective effect of chemical modifying agents on their intracellular concentrations

Eidus, L.K.; Korystov, Y.N.; Kublik, L.N.; Vexler, A.M.

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 41(6): 625-632

1982

ISSN/ISBN: 0020-7616
PMID: 6981618
Document Number: 193845
Regularities of the radioprotective effect of chemical modifying agents cysteamine, caffeine benzoate, thioglycolic acid and caffeine, all weak electrolytes, were studied in cultured Chinese hamster cells. Efficiency of protection is dependent on pH and concentrations of the drug inside the cells and in the medium. Based on the theory of the dissociation of weak electrolytes and their distribution between the cells and the medium, a strong correlation between the efficiency of modification of the radiation response and intracellular concentration of a modifying agent is shown.

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