Hemodynamic reaction of normotensive and hypertensive rats to the administration of prostaglandins and indomethacin
Ismailov, S.I.; Val'dman, A.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 94(8): 45-48
1982
ISSN/ISBN: 0365-9615 PMID: 6751430 Document Number: 193567
Experiments on anesthesized normotensive rats (NR), spontaneous-hypertensive rats (SHR) and rats with experimental renovascular hypertension (RVR) were made to study the effect of prostaglandins (PG) - PGI2, PGE1, PGF2, and indomethacin on systemic hemodynamics, pressor reaction and cardiac component of the baroreflex. PGI1 (0.015 microgram/kg) PGE1 (5 micrograms/kg) produced marked hypotension which was more remarkable in RVR and SHR than in NR. The hypotensive effect of both PG was determined by peripheral vasodilatation. After administration of PGI2 and PGE1 the baroreflex appreciably rises in hypertensive rats. PGE2 (10 micrograms/kg) elevates arterial blood pressure in NR to a greater degree than in RVR and SHR. Indomethacin (10 mg/kg) raises the pressure by 33% in NR, by 16% in SHR and by 5% in RVR. At the same time baroreflex sensitivity in NR declines by 208%.