Effect of inotropic factors in the postload characteristics of the heart
Orlova, T.R.; Ragimov, S.E.; Shlain, V.A.; Sakharov, M.P.; Trubetskoĭ, A.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(6): 5-7
1982
ISSN/ISBN: 0365-9615 PMID: 7115936 Document Number: 192503
It was shown in acute experiments on cats that the post-exercise characteristics of the left ventricle plotted as a dependence between the magnitudes of the maximal blood flow velocity and systolic intraventricular pressure in health and inotropic exposures are close to the linear ones. Adrenaline shifts the post-exercise characteristics upward and to the right, increasing both the maximal magnitude of the blood flow velocity at a zero pressure (velocity component) and the maximal magnitude of the pressure at a zero blood flow (force component), the latter rising to a greater extent. Calcium chloride and obsidan cause a parallel shift of the post-exercise characteristics: the force and velocity components diminish upon obsidan administration, while with CaCl2 they increase.