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Effect of thymic polypeptide factor on the cyclic nucleotide system of immunocompetent cells

Morozov, V.G.; Khavinson, V.K.; Kozhemiakin, A.L.; Kozhemiakin, L.A.

Voprosy Meditsinskoi Khimii 28(4): 114-118

1982

ISSN/ISBN: 0042-8809
PMID: 6981253
Document Number: 192387
Thyramine, a polypeptide factor from thymus, at wide range of concentrations increased the cAMP content in rat thymocytes. Increase in the cAMP content was less distinct in spleen lymphoid cells. Thyramine decreased the cGMP content in thymocytes; minimal nucleotide level was found within 15 min of incubation. The data obtained suggest that the rate of lymphocyte maturation is important for response of the cells to the effect of immunoregulating agents.

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