Lymphocyte activation by low doses of cyclosporin A

Diener, C.; Haroske, D.; Metzner, G.; Jäger, L.; Diener, C; Haroske, D; Metzner, G; Jäger, L

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Lymphocyte activation by low doses of cyclosporin A

Diener, C.; Haroske, D.; Metzner, G.; Jäger, L.

Acta Biologica et Medica Germanica 41(6): 549-552

1982

ISSN/ISBN: 0001-5318

PMID: 7148266

Document Number: 192086

Supernatants of human lymphocyte cultures incubated with cyclosporin A (CS-A) for 90 min reveal an inhibitory effect on the electrophoretic mobility of guinea pig macrophages. This effect is distinctly demonstrated already at CS-A concentrations from 10-7 .mu.g/ml on, with a maximum at 10-3 .mu.g/ml. An inhibitory action of CS-A on PHA).