Experimentally induced tumors used for angiographic estimation of embolisation and cytostatic treatment
Strecker, E.P.; Kraus, W.; Fiebig, H.H.; Kauffmann, G.; Hauenstein, K.H.
Der Radiologe 22(2): 92-97
1982
ISSN/ISBN: 0033-832X PMID: 7071330 Document Number: 192061
In 12 rats tumors were induced chemically by i.p. application of dimethylnitrosamine. This method is simple and reliable and the effect of tumor embolization can be followed easily. Thymus aplastic nude mice with transplanted human tumors deserve strict care. Tumor microangiograms of 48 animals demonstrate a close similarity with angiograms of corresponding human tumors. The vascular pattern does not alternate after several transplantations and after cytostatic therapy [including 5-fluorouracil, adriblastine, vincristine and endoxan] a slight hypervascularization develops.