Age characteristics of lipid peroxide oxidation induction in the rat liver during fasting
Lemeshko, V.V.; Nikitchenko, I.V.; Kaliman, P.A.
Ukrainskii Biokhimicheskii Zhurnal 54(3): 325-327
1982
ISSN/ISBN: 0201-8470 PMID: 7101479 Document Number: 191810
The peroxide oxidation of lipids, both spontaneous and NADPH-induced, was studied in incubation of the liver homogenate postnuclear fraction for rats aged 1, 3, 12 and 24 months. Fasting increases significantly the rate of NADPH-dependent accumulation of malonic dialdehyde, the absolute growth value of which was almost the same in 1,3 and 24-month rats and higher than in the middle-aged animals. A relative increase in the lipid peroxide oxidation intensity during fasting as compared to the norm is more sharply pronounced in old rats.