Treatment of condyloma acuminatum with 0.5% 5-fluorouracil-solution, a double-blind clinical trial
Weismann, K.; Kassis, V.
Zeitschrift für Hautkrankheiten 57(11): 810-816
1982
ISSN/ISBN: 0301-0481 PMID: 7048776 Document Number: 189399
30 males and 29 females with condyloma acuminatum took part in a double-blind randomized trial with 0,5% 5-fluorouracil (5-FU) salicylic acid containing varnish for warts versus the varnish without 5-FU. The females were treated twice weekly at the clinic, the males were treated once daily at home by themselves. The 5-FU solution was found significantly superior to placebo (P less than 0,01). 60% of the 5-FU treated patients were healed with a median healing time of two weeks in the males and three weeks in the females. In the placebo group 27,6% healed with a median healing time of 2,5 weeks (males) an 3,5 weeks (females). Blood tests obtained before and after the trial were normal. Patch tests with 0,5% 5-FU revealed no sensitization after the therapy.