Thiourea prevents cytotoxicity and mutagenicity, but not sister-chromated exchanges in V79 cells treated with cis-diaminedichloroplatinum (II)
Bradley, M.O.; Patterson, S.; Zwelling, L.A.
Mutation Research 96(1): 67-74
1982
ISSN/ISBN: 0027-5107 PMID: 6811892 Document Number: 189049
cis-Dimaminedichloroplatinum(II)'s (cis-DDP) mutagenicity, as well as its cytotoxicity, can be prevented by subsequent treatment with thiourea. Sister-chromatid exchanges (SCE) induced by cis-DDP are only partially prevented by thiourea under conditions where mutagenicity is totally inhibited. A 4.5-h delay in the addition of thiourea following cis-DDP treatment results in an almost complete loss of its ability to prevent mutagenicity, but only a partial loss of its ability to prevent cytotoxicity and sister-chromatid exchanges.