The effect of pirenzepine on esophageal motility
Erckenbrecht, E.; Berges, W.; Sonnenberg, A.; Erckenbrecht, J.; Wienbeck, M.
Scandinavian Journal of Gastroenterology. Suppl 72: 185-190
1982
ISSN/ISBN: 0085-5928 PMID: 6957989 Document Number: 188958
The effect of pirenzepine on esophageal motility was studied in ten healthy volunteers by manometry. Pirenzepine reduces lower esophageal sphincter pressure (LESP), amplitude, and duration of esophageal contractions, but it increases velocity of propagation of esophageal contractions. On the other hand, it is known that pirenzepine inhibits gastric acid secretion. Therefore, the reduction of contractile force in the esophagus caused by pirenzepine does not necessarily mean an increased risk of peptic gastroesophageal reflux.