Top Abstract Purchase Related
Home
>
Node
>
Subnode

Comparative cardiovascular effects of antidepressants in animals and man

Lindbom, L.O.; Groschinsky-Grind, M.; Forsberg, T.

Journal of Clinical Psychiatry 43(5 Part 2): 32-34

1982

ISSN/ISBN: 0160-6689
PMID: 7076636
Document Number: 188311
Various opinions have been offered regarding the possibility of extrapolation to man of findings in animals on cardiovascular effects of antidepressants. The present study examines this question by correlating ECG and heart rate effects of antidepressants given to rats to similar effects in clinical studies. For the QRS width and the QT length, correlation were found indicating that at least qualitative extrapolations can be made. For PR length and heart rate, the lack of correlations indicates that effects on variables dependent on more complex regulatory systems are more difficult to predict.

Document emailed within 1 workday
Secure & encrypted payments

Biamino, G.; Fenner, H.; Schüren, K.P.; Neye, J.; Ramdohr, B.; Lohmann, R.W. 1975: Cardiovascular side effects of tricyclic antidepressants - a risk in the use of these drugs International Journal of Clinical Pharmacology and Biopharmacy 11(3): 253-261
Zácková, P.; Kunová, A.; Benetková, M. 1989: Different cardiovascular effects of tricyclic antidepressants in the conscious and anesthetized rats Activitas Nervosa Superior 31(1): 31-32
Pacher, P.ál.; Kecskeméti, V.ér. 2004: Cardiovascular effects of selective serotonin reuptake inhibitor antidepressants Orvosi Hetilap 145(8): 425-431
Goldman, L.S.; Alexander, R.C.; Luchins, D.J. 1986: Monoamine oxidase inhibitors and tricyclic antidepressants: comparison of their cardiovascular effects Journal of Clinical Psychiatry 47(5): 225-229
Lipscomb, P.A. 1980: Cardiovascular side effects of phenothiazines and tricyclic antidepressants. A review with precautionary measures Postgraduate Medicine 67(3): 189-92 195-6
Pacher, P.; Ungvari, Z.; Kecskemeti, V.; Furst, S. 1998: Review of cardiovascular effects of fluoxetine, a selective serotonin reuptake inhibitor, compared to tricyclic antidepressants Current Medicinal Chemistry 5(5): 381-390
Biamino, G.; Fenner, H.; Neye, J.; Schuren, K.P.; Ramdohr, B. 1975: Comparative in vitro and in vivo studies on the effects of tricyclic antidepressants on myocardial contractility Recent Advances in Studies on Cardiac Structure and Metabolism 10: 59-69
Ohtsuka, M.; Koibuchi, Y.; Sakai, S.; Tsujioka, K.; Fujiwara, T.; Ozaki, T.; Maeda, K.; Motoyama, I.; Horiai, H.; Ono, T. 1988: Effects of nilvadipine on the cardiovascular system in experimental animals Arzneimittel-Forschung 38(11): 1605-1618
Rozonov, I.B. 1976: Cardiovascular effects of diazepam and chlordiazepoxide in experiments on non-narcotized animals Farmakologiia i Toksikologiia 39(2): 163-167
Alousi, A.A. 1975: Cardiovascular effects of dopamine in the normal and failing heart of experimental animals Recent Advances in Studies on Cardiac Structure and Metabolism 6: 291-300
Van Dorsser, W.; Dresse, A. 1974: Comparative effects of various antidepressants on the response to noradrenaline of the deferent canal and the arterial pressure, and the response to 5-hydroxytryptamine of the rat uterus Archives Internationales de Pharmacodynamie et de Therapie 208(2): 373-376
Klinskiĭ, I.D.; Paducheva, A.L.; Komarova, Z.B.; Smirnov, L.A.; Murav'ev, M.I. 1977: Comparative studies on the effects of hormone preparations on meat building in farm animals Archiv für Experimentelle Veterinarmedizin 31(6): 951-957
Benesová, O. 1970: Is it possible to predict the clinical effect of antidepressants from experimental data in animals? Activitas Nervosa Superior 12(2): 127-128
Mosca, S.M.; Gelpi, R.J.; Cingolani, H.E. 1987: Comparative cardiovascular effects of nifedipine in anesthetized dogs Acta Physiologica et Pharmacologica Latinoamericana: Organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia 37(4): 467-477
Jackson, W.K.; Roose, S.P.; Glassman, A.H. 1987: Cardiovascular toxicity and tricyclic antidepressants Biomedicine and PharmacoTherapy 41(7): 377-382
Seitz, W.; Hempelmann, G.; Schleussner, E.; Piepenbrock, S. 1981: Comparative clinical investigations on the cardiovascular effects of piritramide (dipidolor) and fentanyl Der Anaesthesist 30(4): 179-184
Stepanov, S.A. 1971: A comparative evaluation of the results of experiments studying the effects of different types and fractions of cereal dust on the respiratory organs of animals Gigiena Truda i Professional'nye Zabolevaniya (8): 44-45
De Castro, J.; Van de Water, A.; Wouters, L.; Xhonneux, R.; Reneman, R.; Kay, B. 1979: Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. II. Comparative study on the epileptoid activity of the narcotics used in high and massive doses in curarised and mechanically ventilated dogs Acta Anaesthesiologica Belgica 30(1): 55-69
Barret, R.J.; Buckenheimer, T.J.; McGuirk, B.A.; Kau, S.T. 1987: Comparative cardiovascular effects of loop-acting, thiazide-type and potassium-sparing diuretics in spontaneously hypertensive rats Methods and Findings in Experimental and Clinical Pharmacology 9(2): 67-78
Devroye, A.; Pinchard, A. 1971: Comparative profiles of current main antidepressants Acta Psychiatrica Belgica 71(4): 320-326