A comparative longitudinal study on sex hormone binding globulin capacity during estrogen replacement therapy
Helgason, S.; Damber, J.E.; Damber, M.G.; von Schoultz, B.; Selstam, G.; Södergård, R.
Acta Obstetricia et Gynecologica Scandinavica 61(2): 97-100
1982
ISSN/ISBN: 0001-6349 PMID: 7113697 Document Number: 188254
An aqueous 2-phase equilibrium partition system was used to assay SHBG were analyzed. The induction of SHBG showed considerable differences between different estrogens. Ethynyl-estradiol in a daily dose of 0.05 mg gave a 70% increase in the serum concentration of this liver derived protein. Estradiol-17.beta., 2 mg daily and estrone sulfate 1.25 mg gave moderate changes, whereas estriol in different doses had no effect. SHBG induction may reflect estrogen overtreatment.
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