Mathematical modelling of intravascular thyroid hormone stimulation by carrier proteins
Geiseler, D.; Wahl, R.; Kallee, E.
Methods and Findings in Experimental and Clinical Pharmacology 4(1): 73-78
1982
ISSN/ISBN: 0379-0355 PMID: 6806550 Document Number: 187952
A simple mathematical model for the thyroid hormone stimulation in plasma after i.v. administration of pharmacological doses of thyroid hormone binding carrier proteins is described. The model concept is based on the observation of the time course of both radioactive labeled and unlabeled thyroid hormones before and after protein loading in rabbits. All model parameters are derived from experimental measurements to guarantee the identifiability with physiological data. A more effective therapy of humor thyroid storm by dialysis or plasma exchange methods is proposed.