Evidence for the role of androgens in the feedback control of gonadotrophin secretion in the human female
Gray, P.; Potgieter, G.M.; Slabber, C.F.; Veldsman, J.J.
South African Medical Journal 61(22): 837-838
1982
ISSN/ISBN: 0256-9574 PMID: 6805081 Document Number: 187950
The effect of androgens on the luteinizing hormone (LH) response to LHRH is fairly well documented. However, the evidence concerning the effect on FSH is less convincing and clear-cut. LHRH was administered to a patient with an androgen-producing adrenal tumor both before and after removal of the tumor. Before operation, testosterone levels were elevated and estradiol levels reduced. There was no response of either LH or FSH levels to LHRH on 2 separate occasions. Postoperatively LH and FSH values rose sharply, to 404% and 170% above basal levels, respectively. Androgens apparently do play a role in the feedback control of both LH and FSH secretion.