Focal segmental glomerular hyalinosis: a special form of fibroplastic glomerulonephritis
Serov, V.V.; Kupriianova, L.A.; Varshavskiĭ, V.A.; Pal'tsev, M.A.; Nikolaev, A.Iu.
Arkhiv Patologii 44(7): 24-29
1982
ISSN/ISBN: 0004-1955 PMID: 7125935 Document Number: 186266
Focal segmentary glomerular hyalinosis (FSGH) presenting a picture of glomerulonephritis of the nephrotic type was characterized morphologically. Clinico-morphological criteria for diagnosis are presented. FSGH is characterized by a severe nephrotic syndrome, progressive course, and refractoriness to immunosuppressive therapy, focal and segmentary pattern of changes in the glomeruli, the presence of hyalin masses in some lobules of glomerular capillaries, lipid inclusions in mesangial and endothelial cells, tubular epithelial cells and interstitum, as well as uneven outlines of the endothelial surface of the basal membrane of glomerular capillaries. The diagnosis of early changes in FSGH require light microscopic and immunohistochemical examinations of kidney biopsies. The problems of the etiology and pathogenesis of FSGH and its independence as a nosological entity are discussed.