Induction of B cell differentiation in vitro by bursal epithelium
Eerola, E.; Lassila, O.; Gilmour, D.G.; Toivanen, A.
Journal of Immunology 128(6): 2652-2655
1982
ISSN/ISBN: 0022-1767 PMID: 6978910 Document Number: 186075
The inductive capacity of in vitro cultured epithelium of chicken bursa of Fabricius and of its soluble products on B cells precursors was evaluated. The appearance of surface Ia-like antigens was used as an indicator of the early B cell differentiation in vitro. Cultured bursal epithelium as well as soluble substances produced by it were able to initiate B cell development; Ia alloantigens were induced by both syngeneic and allogeneic epithelia. In both cases the induced Ia antigens represented the genotype of the responding cells.