Immunological markers of Langerhans' cells in mycosis fungoides skin lesions
Tjernlund, U.
Acta Dermato-Venereologica 62(3): 241-243
1982
ISSN/ISBN: 0001-5555 PMID: 6179366 Document Number: 186022
The patterns of 2 immunological markers of epidermal Langerhans' cells were compared in normal skin and mycosis fungoides (MF) skin lesions. A double-staining indirect immunofluorescence method was used. Cells suggestive of keratinocytes reacted with the anti-Ia antibodies in some cases of MF lesions, while no such pattern was seen with the thymocyte-antigen antibodies (OK T6). In other cases of MF, as in normal skin, the epidermal picture was mainly the same with the 2 markers. A great many of the dermal mononuclear cells in MF were reactive with the anti-Ia antibodies but only occasional dermal cells in MF and no dermal cells in normal skin stained with OK T6.