Sulfonamides with central nervous system action. V
Monzani, A.; Di Bella, M.; Braghiroli, D.; Raffa, L.; Sandrini, M.
Il Farmaco; Edizione Scientifica 37(3): 151-158
1982
ISSN/ISBN: 0430-0920 PMID: 7067810 Document Number: 186018
A series of 2-nitro and 2-aminobenzenesulfon-N-acylamides variously substituted on the benzene ring were prepared and tested for anticonvulsant activity (electro shock, pentamethylenetetrazole). Some of the compounds tested gave some measure of protection against convulsions induced by electric shock. The importance of the trifluoromethyl substituent in this effect was demonstrated.
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