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Clinical and pharmacokinetic effects of combined warfarin and 5-flourouracil in advanced colon cancer

Chlebowski, R.T.; Gota, C.H.; Chan, K.K.; Weiner, J.M.; Block, J.B.; Bateman, J.R.

Cancer Research 42(11): 4827-4830

1982

ISSN/ISBN: 0008-5472
PMID: 7127318
Document Number: 185653
Patients (25) with advanced, measurable adenocarcinoma of the colon were treated with 5-fluorouracil (FUra), 15-20 mg/kg per wk i.v., plus warfarin p.o. was seen with high (0.6 mg/kg per h), but not low (0.025 mg/kg per h), rates of warfarin infusion. In patients, FUra t1/2 was not changed by therapeutic warfarin anticoagulation. Plasma clearance interaction between FUra and warfarin does not occur in patients receiving therapeutic levels of anticoagulation. FUra and warfarin anticoagulation can be safely given and frequently result in stable disease status for patients with advanced colon cancer. Further trials of this combination are warranted in adenocarcinomas of the colon.

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