Immunity indices of patients with locally disseminated malignant neoplasms of the head and neck
Bulbuk, G.A.
Voprosy Onkologii 28(4): 57-59
1982
ISSN/ISBN: 0507-3758 PMID: 7090271 Document Number: 185632
The study is concerned with the functional state of lymphocytes, granulocytes and levels of immunoglobulins IgG, IgA and IgM in blood serum of patients with local neoplasms of the pharynx, thyroid, oral cavity and tongue. Cancer patients revealed a considerable decrease in the levels of rosette-forming T-lymphocytes, plaque-forming cells and granulocytes, capable of reducing nitroblue tetrazolium, blood serum levels of IgG, IgA and IgM being practically unchanged. There is a relationship between the type of clinical course of disease and severity of immunological disorders in advanced cancer of the pharynx. Immunologic response disturbances are most manifest, when immune surveillance is undermined by tumor process and metastasis development.