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Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain

Harden, T.K.; Mccarthy, K.D.

Journal of Pharmacology and Experimental Therapeutics 222(3): 600-605

1982

ISSN/ISBN: 0022-3565
PMID: 6125583
Document Number: 185579
The .beta.-adrenergic receptor antagonist, hydroxybenzylpindolol predominantly interacted with a single receptor subtype on these cells. Hofstee analysis of zinterol competition curves with membranes from adult rat cerebral cortex were nonlinear, suggesting the presence of 2 binding components. The data are consistent with the conclusion that mainly a single subtype of .beta.-adrenergic receptor exists on astroglia cultured from newborn rat cerebral cortex and that this receptor is of the .beta.1-subtype.

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