Effects of monensin on the processing of pro-opiomelanocortin in the intermediate lobe of the rat pituitary
Crine, P.; Dufour, L.
Biochemical and Biophysical Research Communications 109(2): 500-506
1982
ISSN/ISBN: 0006-291X PMID: 6295399 Document Number: 183995
The effect of monensin on the maturation of proopiomelanocortin, the common precursor to .alpha.-melanotropin and .beta.-endorphin in intermediate lobe cells of the rat pituitary was studied. Monensin can completely inhibit the proteolytic processing of pro-opiomelanocortin but does not interfere with the addition of terminal sugars on carbohydrate side chains as tested by their sensitivity to endo-.beta.-N-acetylglucosaminidase H.