Capacity of diphosphonates to bind calcium and their effect on the osmotic permeability of the frog bladder wall
Shakhmatova, E.I.; Kabachnik, M.I.; Medved', T.I.; Natochin, I.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(6): 71-74
1982
ISSN/ISBN: 0365-9615 PMID: 6810972 Document Number: 183897
Like EDTA, diphosphonates increase permeability of the frog urinary bladder wall for water osmotic gradient. Their effect is proportional to the stability of their binding with calcium ions. The efficacy of diphosphonates falls upon pH decline. The results indicate the significance of Ca binding in cells and membrane action of diphosphonates.
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