Determination of myelin marker enzymes in the blood serum in peripheral nervous system diseases
Savchenko, I.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(4): 34-35
1982
ISSN/ISBN: 0365-9615 PMID: 6282360 Document Number: 183610
The activity of 2',3'-cyclonucleotide-3-phosphohydrolase (CNP) and leucine aminopeptidase (LAP) was studied for the first time in the blood of patients with diseases of the peripheral nervous system. A spectrophotometric method for CNP activity detection was described. The activity absent from the blood of normal subjects was detectable with statistical significance in the patients with the diseases in question. Analogous results were obtained in the animals with an experimental injury to the myelin coat of the peripheral nerves. Study into the activity of LAP in the pathological conditions under consideration revealed no significant deviations. It is emphasized that CNP may transfer to the blood serum from myelin decay foci and that the method described may be used for diagnostic purposes.