Prospective Randomized Trial Comparing the Efficacy of Single 6-ml Injection of Hylan G-F 20 and Hyaluronic Acid for Primary Knee Arthritis: A Preliminary Study
Khanasuk, Y.; Dechmaneenin, T.; Tanavalee, A.
Journal of the Medical Association of Thailand 95(10): 92-97
2012
ISSN/ISBN: 0125-2208 PMID: 23451445 Document Number: 18338
Objective: To compare the efficacy of single 6-ml intraarticular injection between hylan G-F 20 and hyaluronic acid (HA) forknee osteoarthritis Material and Method: Thirty-two patients with primary knee arthritis, who were randomly received single intraarticularinjection of 6-ml hylan G-F 20 (Synvisc) or HA (Hyalgan), were prospectively evaluated for clinical outcomes at aminimum 26-week follow-up. The parameters, including visual analog scale (VAS) during walking, the Western Ontario andMcMaster Universities Osteoarthritis (WOMAC) index and Short-Form 36 (SF-36) questionnaires, were evaluated at preinjection,then at 1 week, 4 weeks, 8 weeks, 12 weeks and 26 weeks, post-injection. Results: There were 15 patients in both groups who were available for final follow-up with no statistical differences indemographic data, VAS during walking, WOMAC score and SF-36 score at pre-injection. There was no adverse event relatedto viscosupplementation using in is better than of both agents. At 26-week follow-up, patients in both groups had significantlyimproved VAS during walking (p 0.01), WOMAC score (p 0.01) and SF-36 (p 0.05) with no statistical differencesbetween groups. However, the cost of hylan G-F 20 was much more expensive than that of HA (534 USD vs. 252 USD). Conclusion: A single intraarticular injection of both hylan G-F 20 and HA for primary knee arthritis had no adverse eventrelated to 6-ml volume. At 26 week follow-up of the present preliminary study, both groups had similarly improved clinicaloutcomes post-injection. Further study in larger population is required. As the cost of hylan G-F 20 was 2 times higher thanHA, a single 6-ml intraarticular injection of HA (Hyalgan) provided better cost-effectiveness than hylan G-F 20 (Synvisc).
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