Increased pulmonary vascular permeability after injection of oleic acid
Hara, N.; Furukawa, T.; Motohiro, H.; Yoshida, T.; Inokuchi, K.
Nihon Kyobu Shikkan Gakkai Zasshi 20(9): 967-973
1982
ISSN/ISBN: 0301-1542 PMID: 7154446 Document Number: 183220
Effects of oleic acid injection (0.1 ml/kg) on pulmonary vascular permeability was examined in 5 anesthetized dogs. In addition to lung water content and histological examination, lung lymph flow, lymph-to-plasma protein ratio and lymph protein clearance were studied as sensitive indicators of transvascular fluid filtration and protein permeability. Lymph protein clearance between oleic acid studies and increased pressure studies was compared to clarify pulmonary vascular permeability. Lung water content increased by 35% in comparison to controls and intraalveolar and interstitial pulmonary edema were demonstrated histologically on the postmortem examination after oleic acid injection. Oleic acid injection caused significant increases in lung lymph flow with no changes in lymph-to-plasma protein ratio. Left atrial hypertension resulted in increases of lung lymph flow that were associated with a decreasing lymph-to-plasma protein ratio. Oleic acid significantly increased lymph protein clearance with an increasing lymph flow, indicating an increase in protein permeability. When lymph protein clearance for a given increase in lymph flow was compared in oleic acid and the increased pressure groups, oleic acid produced a greater increase in protein clearance than that seen after increased pressure. Oleic acid caused an increase in pulmonary vascular permeability, probably due to pulmonary endothelial injuries.