Two cases of skin pigmentation in association with minocycline therapy
Leroy, J.P.; Dorval, J.C.; Dewitte, J.D.; Guillerm, D.; Volant, A.; Masse, R.
Annales de Dermatologie et de Venereologie 108(11): 871-875
1981
ISSN/ISBN: 0151-9638 PMID: 7325520 Document Number: 182622
Report of two cases of skin pigmentation during minocycline therapy. Examination showed confluent blue-gray oval patches on the anterior part of the legs, occurring after ingestion of respectively 12 g and 100 g of minocycline. Microscopic examination of each case was identical and showed two lesions: increase in the amount of melanine deposition in the basal layer of the epidermis; presence of brown-black pigment at all the level of the dermis but specially near the sweet glands. This pigment was strongly positive with Perls' stain. Electron microscopic examination showed a finely granular pigment exclusively intracellular in dermis fibroblast and macrophage. This pigment seemed to contain mainly hemodiderine.