Local rheumatoid therapy. Indomethacin level in the synovia and serum after application of Amuno ointment
Miehle, W.; Rehs, E.L.; Zollner, E.
Fortschritte der Medizin 99(44): 1830-1833
1981
ISSN/ISBN: 0015-8178 PMID: 7308947 Document Number: 182073
9 patients with rheumatoid arthritis and one with activated gonarthrosis were treated by means of application of Amuno ointment to one knee in a dosage of 3 X 5 cm ribbon of ointment, rubbed in on an area of approximately 200 cm2, over a period of 3 days. After this interval in 8 patients the knee-joints not treated with ointment were punctured, and synovial fluid was won. In all 10 cases serum level determinations were carried out. The obtained average values in serum ranged from 114.4 - 134.3 ng/ml, the average value found in the synovial fluid was ascertained at 235.6 ng/ml. Although this report is presenting only intermediate results these may nevertheless serve as evidence for a systemic effect of Amuno ointment at the synovium.