Experimental studies with a thread containing mefenamic acid introduced into the rat uterus
Gupta, U.; Malhotra, N.; Saini, K.C.; Chaudhury, R.R.
Indian Journal of Experimental Biology 19(5): 413-415
1981
ISSN/ISBN: 0019-5189 PMID: 7275202 Document Number: 182004
Prostaglandin synthetase inhibiting drugs have been clinically shown to reduce the bleeding induced by the intrauterine devices. A prostaglandin synthetase inhibitor, mefenamic acid was entrapped in triacetate polymer threads. These threads when introduced into the rat uterine horns demonstrated an anti-implantation activity. The drug was released in the rat uterus as indicated by the chemical assay of the drug content in the threads which were left in the rat uterus for 2 wk. Medicated threads caused less inflammation as compared to the non-medicated threads.
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