Autoantibodies in advanced old-age
Rossi, E.R.; Siccardi, M.
Bollettino della Societa Italiana di Biologia Sperimentale 57(2): 207-211
1981
ISSN/ISBN: 0037-8771 PMID: 7236394 Document Number: 181893
A variety of autoantibodies (anti-nuclear, anti-mitochondrial, anti-smooth muscle, anti-gastric parietal cell) were measured by indirect immunofluorescence. At least one of such autoantibodies was detected in 65.2% of 46 old people sera (ranging from 76 to 95). Both a decrease in the efficiency of the immune response and a failure of the immunoregulatory mechanisms occurring with age may account for the above findings.